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High levels of infl amma-tory cytokines, including interleukin-1 (IL-1), interleukin-6(IL-6), and tumor necrosis factor-? (TNF-?) are found inbrains of AD patients, as compared with normal controls(Bauer et al., 1992; Dickson et al., 1993). Huge strides were made in the late 1980s and early1990s after seminal vascular anatomic studies by Cormack et al led to rationally designedlocal fasciocutaneous and advancement flaps.11,12 Most notable among these includefasciocutaneous flaps based on the internal pudendal vessels such as the neurovascularpudendal thigh flap (also known as the Singapore flap) for vaginal reconstruction andvarious V-Y advancement flaps for vulvar reconstruction

Huge strides were made in the late 1980s and early1990s after seminal vascular anatomic studies by Cormack et al led to rationally designedlocal fasciocutaneous and advancement flaps.11,12 Most notable among these includefasciocutaneous flaps based on the internal pudendal vessels such as the neurovascularpudendal thigh flap (also known as the Singapore flap) for vaginal reconstruction andvarious V-Y advancement flaps for vulvar reconstruction. cularized retina to stage 5 marked by a total reti-Better monitoring of supplemental oxygen and nal detachment

cularized retina to stage 5 marked by a total reti-Better monitoring of supplemental oxygen and nal detachment.

(Above, left) Vulvar wound followingradical vulvectomy and lymphadenectomy, with bilateral medial thigh V-Yadvancementflaps outlined.

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